Zomwe zimakula ndi mankhwala opangira (opangidwa ndi anthu) omwe amalimbikitsa maselo kugawanika ndi kukula. Pali zinthu zambiri zakukula zomwe zimakhudza mitundu yosiyanasiyana ya ma cell. Thupi lanu limapanga zinthu zakukulira mwachilengedwe.
Kodi kukula kwa zinthu ndi chiyani?
Granulocyte-colony stimulating factor (G-CSF) imapangidwa m'thupi ndi chitetezo chamthupi ndipo imathandizira kupanga mtundu umodzi wa cell yoyera yamagazi, neutrophil. Ma neutrophils amatenga nawo gawo pakutupa ndipo ali ndi udindo wozindikira ndikuwononga mabakiteriya owopsa, ma virus, ndi mafangasi ena.
Zinthu zina zakukula zimatha kupangidwanso mu labotale. Izi zitha kugwiritsidwa ntchito kulimbikitsa kupanga maselo atsopano mwa odwala omwe amawafuna.
Mitundu yosiyanasiyana ya G-CSF ingagwiritsidwe ntchito:
- Lenograstim (Granocyte®)
- Filgrastim (Neupogen®)
- Lipegfilgrastim (Lonquex®)
- Pegylated filgrastim (Neulasta®)
Ndani amafunikira zinthu zakukula?
Kaya chithandizo cha G-CSF chikufunika kapena ayi zimadalira:
- Mtundu ndi siteji ya lymphoma
- The chemotherapy
- Kaya neutropenic sepsis idachitika kale
- Thandizo lakale
- Age
- Umoyo wathanzi
Zizindikiro za G-CSF
Pali zifukwa zingapo zomwe odwala lymphoma angafunikire kulandira G-CSF. Zifukwa zingaphatikizepo:
- Pewani sepsis ya neutropenic. Chemotherapy ya lymphoma imafuna kupha maselo a lymphoma koma maselo ena athanzi amathanso kukhudzidwa. Izi zikuphatikizapo maselo oyera a magazi otchedwa neutrophils. Kuchiza ndi G-CSF kumathandiza kuti ma neutrophil achire msanga. Itha kugwiritsidwa ntchito kuchepetsa chiopsezo cha neutropenic sepsis. Angathenso kupewa kuchedwa kapena kuchepetsa mlingo wa mankhwala a chemotherapy.
- Kuchiza neutropenic sepsis. Neutropenic sepsis ndi pamene wodwala amene ali ndi mlingo wochepa wa neutrophils atenga matenda omwe sangawamenye ndikukhala septic. Ngati salandira chithandizo chamankhwala mwachangu, zitha kukhala zowopseza moyo.
- Kupititsa patsogolo kupanga ndi kusonkhanitsa maselo a stem musanayambe kuyika mafupa. Zomwe zimakula zimalimbikitsa mafupa kuti apange maselo ambiri. Amawalimbikitsanso kuti atuluke m’mafupa n’kulowa m’magazi, kumene angasonkhanitsidwe mosavuta.
Amaperekedwa bwanji?
- G-CSF imaperekedwa ngati jekeseni pansi pa khungu (subcutaneously)
- Jekeseni woyamba amaperekedwa kuchipatala kuti ayang'anire zomwe zikuchitika
- Namwino amatha kuwonetsa wodwala kapena wothandizira momwe angayankhire G-CSF kunyumba.
- Namwino wa mdera atha kupita tsiku lililonse kukapereka jakisoni, kapena angaperekedwe kwa GP.
- Nthawi zambiri amabwera m'majakisoni osagwiritsidwa ntchito kamodzi, odzazidwa kale
- Majekeseni a G-CSF ayenera kusungidwa mu furiji.
- Chotsani jekeseni mu furiji mphindi 30 musanafunike. Ndi bwino ngati kuli kutentha kwa chipinda.
- Odwala ayenera kuyeza kutentha kwawo tsiku lililonse ndikukhala tcheru ndi zizindikiro zina za matenda.
Zotsatira za jakisoni wa G-CSF
Miyezo ya maselo oyera a magazi m'thupi idzayesedwa nthawi zonse ndikuyezetsa magazi pamene odwala akulandira jakisoni wa G-CSF.
Zotsatira zoyipa zambiri
- nseru
- kusanza
- Kupweteka kwa mafupa
- malungo
- kutopa
- Kutaya tsitsi
- Kutsekula m'mimba kapena kudzimbidwa
- chizungulire
- Rash
- litsipa
Zindikirani: odwala ena amatha kudwala kwambiri mafupa, makamaka m'munsi kumbuyo. Izi zimachitika pamene jakisoni wa G-CSF amayambitsa kuwonjezeka kwachangu kwa neutrophils ndi kuyankha kwa kutupa m'mafupa. Mafupa amakhala makamaka m'chiuno (chiuno / kumunsi kumbuyo). Izi zimachitika pamene maselo oyera a magazi akubwerera. Wamng'ono wodwala ndi ululu kwambiri, monga m`mafupa akadali wandiweyani ndithu ali wamng'ono. Wodwala wamkulu amakhala ndi mafupa ochepa kwambiri ndipo nthawi zambiri amamva ululu koma osati nthawi zonse. Zinthu zomwe zingathandize kuchepetsa kukhumudwa:
- Paracetamol
- Kutentha paketi
- Loratadine: antihistamine yomwe imachepetsa kutupa
- Lumikizanani ndi gulu lachipatala kuti mulandire mankhwala ochepetsa ululu ngati zomwe zili pamwambazi sizikuthandizani
Nenani zotsatira zoyipa zilizonse ku gulu lanu lazaumoyo.
Zotsatira zoyipa
Odwala ena amatha kukulitsa ndulu. Uzani dokotala ngati muli ndi:
- Kumva kukhuta kapena kusapeza bwino kumanzere kwa pamimba, pansi pa nthiti
- Ululu kumanzere kwa mimba
- Ululu kumapeto kwa phewa lakumanzere
