Pali mankhwala ambiri omwe angaperekedwe ngati chithandizo chapakamwa (pakamwa) cha lymphoma ndi chronic lymphocytic leukemia.
Mwachidule zamankhwala amkamwa mu lymphoma (& CLL)
Chithandizo cha Lymphoma ndi Lymphocytic Lymphoma (CLL) chikhoza kukhala kuphatikiza kwa mankhwala oletsa khansa. Nthawi zambiri amaperekedwa mumtsempha (mtsempha) ndipo nthawi zambiri amaphatikiza mankhwala ophatikizika kuphatikiza antibody therapy ndi chemotherapy (immunochemotherapy).
Izi nthawi zambiri zimaphatikizapo kupereka chithandizo ku chipatala kapena ku malo apadera a khansa. Komabe, pakhala pali zochitika zambiri za khansa zochizira lymphoma ndi CLL zomwe zimatha kutengedwa pakamwa pamapiritsi. Mankhwalawa amadziwika kuti machiritso a pakamwa.
Kodi chithandizo chamkamwa ndi chiyani?
Mankhwala a oral lymphoma amatha kukhala mankhwala a chemotherapy, mankhwala ochizira, komanso ma immunotherapies. Amatha kutengedwa pakamwa ngati piritsi, kapisozi, kapena ngati madzi. Mankhwalawa amalowetsedwa m'magazi ndikuyenda mozungulira ngati mankhwala olowetsa mtsempha.
Kuchiza pakamwa kumatha kukhala kothandiza ngati njira yolowera m'mitsempha komanso kumakhala ndi zovuta zina. Pali zinthu zambiri zokhudzana ndi kagawo kakang'ono ka lymphoma ndi momwe wodwalayo alili, zomwe ziyenera kukhala zoyenera kuti asankhe chithandizo chabwino kwambiri cha lymphoma. Choncho, kusankha kumapangidwa bwino pokambirana ndi katswiri.
Kodi chithandizo chamkamwa chimagwiritsidwa ntchito liti?
Mankhwala ambiri apakamwa omwe amagwiritsidwa ntchito pochiza matenda a lymphoma ndi CLL ndi othandizira a immunotherapy kapena mankhwala omwe akuwongolera. Njira zochiritsira zomwe zimayang'aniridwa ndizomwe zimagwiritsidwa ntchito motsutsana ndi ma enzymes omwe amafunikira kuti lymphoma ikule pomwe mankhwala wamba a chemotherapy amawongoleredwa motsutsana ndi ma cell omwe amagawika mwachangu kaya ndi ma lymphoma kapena maselo ena abwinobwino m'thupi la munthu.
Monga mankhwala a chemotherapy samasiyanitsa pakati pa maselo a lymphoma ndi maselo abwinobwinobwino amawononga mosadziwa maselo abwinobwino zomwe zimatsogolera ku zotsatira zoyipa monga kuchepa kwa magazi, kutayika tsitsi, zilonda zapakamwa, nseru, kusanza ndi kutsekula m'mimba pomwe njira zochiritsira zomwe zimayang'aniridwa nthawi zambiri zimakhudza maselo athanzi ochepa. mu zochepa mwa mitundu iyi ya zotsatira zoyipa.
Kuyamba chithandizo chamankhwala pakamwa
Odwala asanayambe kulandira chithandizo kunyumba:
- Dokotala adzapereka chithandizo
- Katswiri wa zamankhwala adzapereka mankhwala kwa wodwalayo
- Kukonzekera kudzakonzedwa kuti akambirane za chithandizo ndi zotsatirapo zomwe zingachitike
Namwino kapena wazamankhwala afotokoze mwatsatanetsatane momwe angamwe mankhwalawo ndipo izi ziphatikizanso mlingo ndi kuchuluka kwake komwe akuyenera kutengedwa. Malangizo adzaperekedwa pa kasamalidwe kotetezeka ndi kasungidwe ka mankhwala. Zotsatira zonse za mankhwalawa zidzakambidwa, ndipo zolembedwa zidzaperekedwa kwa wodwalayo.
Zinthu zoti mudziwe zokhudza kumwa mankhwala ochiritsira pakamwa
Chithandizo cha khansa yapakamwa chingakhale njira yabwino kwa odwala monga momwe angatengedwere kunyumba, komabe pali zinthu zingapo zomwe muyenera kuziganizira:
- Odwala ali ndi udindo wowonetsetsa kuti amwa mankhwala, chifukwa chake pangakhale chiopsezo chowonjezereka cha zolakwika za mankhwala monga kuiwala kumwa mankhwala.
pamasiku ena kapena kumwa mlingo wolakwika zomwe zingasokoneze mphamvu ya mankhwala. - Ndikofunikira kuti odwala amwe mankhwala onse monga momwe akufunira kuti chithandizocho chikhale chogwira mtima komanso kuti achepetse zovuta zilizonse. Popeza kutsata mankhwala onse kungakhale kovuta, lankhulani ndi gulu la akatswiri za momwe mungayendetsere bwino. Zida zosiyanasiyana zitha kukhala zothandiza kuphatikiza kujambula mankhwala mu diary kapena kupanga zikumbutso pa intaneti mu mapulogalamu kapena pa foni yam'manja
- Odwala angamve kuti ali ndi chidwi chochepa ndi gulu lawo la akatswiri kuposa momwe amachitira akanakhala akulandira mankhwala olowetsedwa m'mitsempha chifukwa amapita kuchipatala kapena kumalo a khansa yachipatala kawirikawiri. Komabe, kumwa mankhwala apakamwa kunyumba kungakhale kopindulitsa kwa odwala omwe amayenera kuyenda ulendo wautali kupita ku chipatala chawo malinga ndi nthawi ndi ndalama zomwe zimagwiritsidwa ntchito paulendo.
- Zotsatira zake zitha kukhala zosazindikirika kapena kusafotokozeredwa ku gulu la akatswiri ndipo zovomerezeka zitha kukhala zosatsimikizika momwe mungasamalire zovuta zoyipa kunyumba. Choncho, n’kofunika kuphunzitsa odwala ndi owasamalira pa mbali zofunika zimenezi. Zotsatira zambiri za mankhwala a pakamwa zimatha kuchepetsedwa ndi chithandizo chothandizira kotero odwala ayenera kuyang'anitsitsa zotsatira zonse za chithandizo chawo ndikuwuza gulu la akatswiri pamene achitika, kuti alandire chithandizo chabwino kwambiri.
Chenjezo mukamamwa mankhwala amkamwa kunyumba
Kuyamba chithandizo kunyumba:
- Chithandizo chamkamwa sichiyenera kugwiridwa ndi manja opanda kanthu. Zitha kuyambitsa kuyabwa
- Sambani m'manja bwino ndi sopo ndi madzi mukamaliza kugwiritsa ntchito mankhwala
- Valani magolovesi posintha zovala kapena zofunda zomwe zili ndi masanzi kapena kutsekula m'mimba
- Sungani mapiritsi monga mwalangizidwa ndi wamankhwala
- Sungani mapiritsi motetezeka kutali ndi ana ndi ziweto
- Tengani chithandizo cham'kamwa ndendende monga mwanenera
- Khalani ndi mndandanda wamankhwala onse omwe alipo
- Konzekerani za maulendo, kudzazanso, ndi kumapeto kwa sabata
- Ngati simukumva bwino nthawi iliyonse funsani gulu lanu lazaumoyo
- Auzeni azaumoyo ena aliwonse za mankhwala oletsa khansa yapakamwa
- Bweretsani mankhwala onse osagwiritsidwa ntchito ku pharmacy kuti atayike bwino
Mitundu yamankhwala amkamwa
TGA yovomerezeka (TGA ndi Therapeutic Goods Authority ku Australia) Thandizo la khansa yapakamwa ndi mankhwala omwe amalepheretsa kukula ndikulimbikitsa kufa kwa maselo a lymphoma. Njira zina zochizira chitetezo cha m'thupi zimalimbikitsa chitetezo cha mthupi cha wodwalayo kuzindikira maselo a lymphoma ndikulimbikitsa kuwonongedwa kwa maselowa. Pali magulu angapo a mankhwalawa omwe alembedwa pansipa:
Oral chemotherapy amagwiritsidwa ntchito pa lymphoma
wothandizila |
Maphunziro |
Momwe ntchito |
Magulu ang'onoang'ono |
Zotsatira zoyipa kwambiri |
| Cyclophosphamide | Chemotherapy: Alkylating wothandizira | Mankhwala amasintha DNA kuti iwononge maselo omwe amakula | CLL HL NHL | Magazi otsika Kutenga Mseru & kusanza Kutaya njala |
| Etoposide | Chemotherapy: Topoisomerase II inhibitor | Imasokoneza ma enzymes a topoisomerase omwe amawongolera kusintha kwa kapangidwe ka DNA kofunikira pakubwereza. | Mtengo wa CTCL NHL | Mseru & kusanza Kutaya njala Kutsekula m'mimba kutopa |
| Chlorambucil | Chemotherapy: Alkylating wothandizira | Mankhwala amasintha DNA kuti iwononge maselo omwe amakula | CLL FL HL NHL | Magazi otsika Kutenga Mseru & kusanza Kutsekula m'mimba |
Mankhwala ena amkamwa omwe amagwiritsidwa ntchito mu lymphoma
wothandizila |
Maphunziro |
Momwe ntchito |
Magulu ang'onoang'ono |
Zotsatira zoyipa kwambiri |
| Anayankha | BTK Inhibitor | Imalepheretsa enzyme yomwe imakhudzidwa ndi chizindikiro cha B cell receptor chofunikira kuti ma cell a lymphoma apulumuke komanso kukula | CLL MCLs | Mavuto amtundu wamtima Matenda odzola Kuthamanga kwa magazi · Matenda |
| Acalabrutinib | BTK inhibitor | Imalepheretsa enzyme yomwe imakhudzidwa ndi chizindikiro cha B cell receptor chofunikira kuti ma cell a lymphoma apulumuke komanso kukula | CLL MCLs | mutu Kutsekula m'mimba kulemera phindu |
| Zanubrutinib | BTK inhibitor | Imalepheretsa enzyme yomwe imakhudzidwa ndi chizindikiro cha B cell receptor chofunikira kuti ma cell a lymphoma apulumuke komanso kukula | CLL MCLs WM | Magazi otsika Rash Kutsekula m'mimba |
| Idelalisib | P13K Inhibitor | Imalepheretsa enzyme yomwe imakhudzidwa ndi chizindikiro cha B cell receptor chofunikira kuti ma cell a lymphoma apulumuke komanso kukula | CLL FL | Kutsekula m'mimba Mavuto a chiwindi Matenda a m'mapapo |
| Kutsegula | BCL2 Inhibitor | Mapuloteni omwe amadziwika kuti amateteza maselo a lymphoma kuti asafe | CLL | nseru Kutsekula m'mimba Mavuto otuluka magazi Matenda |
| Lenalidomide | Immunomodulatory wothandizira | Makina enieni osadziwika. Amaganiza kusintha chitetezo cha m'thupi. | Amagwiritsidwa ntchito mu ma NHL ena | Zotupa pakhungu Mseru Kutsekula m'mimba |
| Vorinostat | HDAC Inhibitor | Imalepheretsa ma enzymes a HDAC ofunikira kuti awonetse majini mu DNA kuti aletse kukula kwa maselo a lymphoma ndi kugawanika. | Mtengo wa CTCL | Kutaya njala pakamwa youma Kutaya tsitsi Matenda |
| Panobinostat | HDAC Inhibitor | Imalepheretsa ma enzymes a HDAC ofunikira kuti awonetse majini mu DNA kuti aletse kukula kwa maselo a lymphoma ndi kugawanika. | HL Mtengo wa CTCL | Mkulu wa magnesium Kuchuluka kwa bilirubin Mseru matenda |
| Bexarotene | Kubwezeretsa | Kusankha kumamanga ndi kuyambitsa ma retinoid receptors zomwe zimapangitsa kuti ma jini azitha kuwongolera kukula ndi kubwerezabwereza | Mtengo wa CTCL | Kuthamanga kwa khungu nseru Mahomoni otsika a chithokomiro matenda |
