Chithunzi chofulumira cha kufalikira kwa B-cell lymphoma (DLBCL) mwa ana
Gawoli ndi kufotokozera mwachidule za kufalikira kwa B cell lymphoma (DLBCL) mwa ana azaka zapakati pa 0-14. Kuti mudziwe zambiri zakuya onani zigawo zowonjezera pansipa.
Ndi chiyani?
Diffuse big B-cell lymphoma (DLBCL) ndi yaukali (ikukula mofulumira) B-cell non-Hodgkin lymphoma. Amachokera ku B lymphocytes (maselo oyera a magazi) omwe amakula mosalamulirika. Ma lymphocyte achilendowa a B amasonkhana m'mitsempha yamagazi ndi ma lymph nodes, mkati mwa lymphatic system, yomwe ili mbali ya chitetezo cha mthupi. Chifukwa minofu ya m'mimba imapezeka m'thupi lonse, DLBCL imatha kuyamba pafupifupi mbali iliyonse ya thupi ndikufalikira pafupifupi chiwalo chilichonse kapena minofu ya thupi.
Kodi zimakhudza ndani?
DLBCL imawerengera pafupifupi 15 peresenti ya ma lymphoma onse omwe amapezeka mwa ana. DLBCL imapezeka kwambiri mwa anyamata kuposa atsikana. DLBCL ndilofala kwambiri la lymphoma subtype mwa akuluakulu, omwe amawerengera pafupifupi 30 peresenti ya anthu akuluakulu a lymphoma.
Chithandizo ndi madokotala ananena zawo
DLBCL mwa ana ali ndi chidziwitso chabwino kwambiri (mawonekedwe). Pafupifupi 90% ya ana amachiritsidwa atalandira chithandizo chamankhwala chokhazikika komanso immunotherapy. Pali kafukufuku wochuluka wokhudza kuchiza lymphoma iyi, ndikugogomezera kufufuza momwe mungachepetsere zotsatira zochedwa, kapena zotsatira za mankhwala oopsa omwe amatha miyezi ingapo pambuyo pa chithandizo.
Mwachidule za kufalikira kwa B-cell lymphoma (DLBCL) mwa ana
Lymphomas ndi gulu la khansa ya dongosolo la lymphatic. Lymphoma imachitika pamene ma lymphocyte, omwe ndi mtundu wa maselo oyera a magazi, amapeza kusintha kwa DNA. Ntchito ya ma lymphocyte ndi kulimbana ndi matenda, monga gawo la thupi chitetezo cha mthupi. Pali B-lymphocyte (B-maselo) ndi T-lymphocytes (ma T-cell) omwe amagwira ntchito zosiyanasiyana.
Mu DLBCL maselo a lymphoma amagawanika ndikukula mosalamulirika kapena samafa pamene ayenera. Pali mitundu iwiri ikuluikulu ya lymphoma. Iwo amatchedwa Hodgkin lymphoma (HL) ndi Non-Hodgkin lymphoma (NHL). Lymphomas imagawidwa m'magulu awiri:
- Indolent (kukula pang'onopang'ono) lymphoma
- Aggressive (kukula mofulumira) lymphoma
- B-cell lymphoma ma B-cell lymphocyte ndi omwe amapezeka kwambiri. B-cell lymphomas ndi pafupifupi 85% ya ma lymphoma onse
- T-cell lymphoma ndi ma T-cell lymphocyte osakhazikika. T-cell lymphomas imakhala pafupifupi 15% ya ma lymphoma onse
Diffuse big B-cell lymphoma (DLBCL) ndi yaukali (ikukula mofulumira) B-cell non-Hodgkin lymphoma. DLBCL imapanga pafupifupi 15 peresenti ya ma lymphoma onse omwe amapezeka mwa ana. DLBCL ndi lymphoma yofala kwambiri mwa akuluakulu, yomwe imakhala pafupifupi 30 peresenti ya milandu yonse ya lymphoma mwa akuluakulu.
DLBCL imayamba kuchokera ku B-maselo okhwima kuchokera ku majeremusi pakati pa lymph node, kapena kuchokera ku B-maselo omwe amadziwika kuti ma B-maselo. Chifukwa chake, pali mitundu iwiri yodziwika bwino ya DLBCL:
- Germinal Center B-cell (GCB)
- Adayambitsa B-cell (ABC)
Chifukwa chenicheni cha DLBCL mwa ana sichidziwika. Nthawi zambiri palibe chifukwa chomveka chofotokozera komwe mwana wadwala khansa ndipo palibe umboni wosonyeza kuti makolo ndi olera/omuyang'anira akanatha kuletsa lymphoma kuti isayambike, kapena kuyambitsa.
Ndani amakhudzidwa ndi kufalikira kwa B-cell lymphoma (DLBCL)?
Kufalikira kwa B-cell lymphoma (DLBCL) kumatha kuchitika mwa anthu azaka zilizonse kapena jenda. DLBCL imapezeka kwambiri mwa ana okulirapo komanso achichepere (anthu azaka 10 - 20 zakubadwa). Amapezeka kawirikawiri mwa anyamata kuposa atsikana.
Chifukwa cha DLBCL sichidziwika. Palibe chimene mwachita kapena simunachite chimene chachititsa zimenezi . Sichipatsirana ndipo sichingapatsidwe kwa anthu ena.
Ngakhale zomwe zingayambitse DLBCL sizodziwikiratu, pali zina zoopsa zomwe zimagwirizana ndi lymphoma. Sikuti anthu onse omwe ali ndi ziwopsezo izi adzapitiliza kupanga DLBCL. Zowopsa zimaphatikizapo (ngakhale chiopsezo chikadali chochepa kwambiri):
- Kachilombo ka Epstein-Barr (EBV) - kachilomboka kamene kamayambitsa matenda a glandular fever
- Chitetezo cha mthupi chofooka chifukwa cha matenda obadwa nawo (matenda a autoimmune monga dyskeratosis congenita, systemic lupus, nyamakazi ya nyamakazi)
- HIV
- Mankhwala a immunosuppressant omwe amatengedwa kuti asakanidwe pambuyo poika chiwalo
- Kukhala ndi mchimwene kapena mlongo yemwe ali ndi lymphoma (makamaka mapasa) akunenedwa kuti ali ndi chibadwa chosowa chokhudzana ndi matendawa (izi ndizosowa kwambiri ndipo sizikulimbikitsidwa kuti mabanja aziyesa majini)
Kukhala ndi mwana yemwe ali ndi matenda a lymphoma kungakhale kovutitsa kwambiri komanso kutengeka maganizo, palibe chabwino kapena cholakwika. Nthawi zambiri zimakhala zowononga komanso zododometsa, ndikofunikira kuti mudzilole nokha ndi banja lanu kukhala ndi nthawi yochita ndi chisoni. Ndikofunikiranso kuti musanyamule kulemera kwa matendawa nokha, pali mabungwe angapo othandizira omwe ali pano kuti akuthandizeni inu ndi banja lanu panthawiyi, Dinani apa kuti mudziwe zambiri za chithandizo cha mabanja omwe ali ndi mwana kapena wachinyamata yemwe ali ndi lymphoma.
Mitundu ya ma diffuse lalikulu B-cell lymphoma (DLBCL) mwa ana
Kufalikira kwa B-cell lymphoma (DLBCL) kumatha kugawidwa m'magulu ang'onoang'ono kutengera mtundu wa B-cell yomwe idachokerako (yotchedwa "cell of origin").
- Germinal Center B-cell lymphoma (GBC): Mtundu wa GCB umapezeka kwambiri mwa odwala kuposa mtundu wa ABC. Achinyamata amatha kutenga matenda amtundu wa GCB (80-95% muzaka 0-20) kuposa akuluakulu ndipo amagwirizana ndi zotsatira zabwino poyerekeza ndi mtundu wa ABC.
- Kuyambitsa B-cell Lymphoma (ABC): Mtundu wa ABC umachokera ku malo a post-germinal center (wa selo) chifukwa ndi okhwima kwambiri a B-cell malignancy. Imatchedwa mtundu wa ABC chifukwa ma B-maselo atsegulidwa ndipo akugwira ntchito ngati othandizira pakuyankha kwa chitetezo chamthupi.
DLBCL ikhoza kugawidwa ngati germinal center B-cell (GCB) kapena activated B-cell (ABC). Katswiri wofufuza ma lymph node biopsy amatha kudziwa kusiyana pakati pa izi poyang'ana mapuloteni ena pa maselo a lymphoma. Pakalipano, chidziwitsochi sichikugwiritsidwa ntchito kutsogolera chithandizo. Komabe, asayansi akuchita kafukufuku kuti adziwe ngati mankhwala osiyanasiyana ali othandiza motsutsana ndi mitundu yosiyanasiyana ya DLBCL yomwe imachokera ku maselo osiyanasiyana.
Zizindikiro zakufalikira kwa B-cell lymphoma (DLBCL) mwa ana
Zizindikiro zoyamba zomwe anthu ambiri amaziwona ndi chotupa kapena zotupa zingapo zomwe sizichoka pakatha milungu ingapo. Mutha kumva chotupa chimodzi kapena zingapo pakhosi la mwana wanu, mkhwapa, kapena ntchafu. Mitsempha iyi ndi ma lymph nodes otupa, pomwe ma lymphocyte osadziwika bwino amakula. Ziphuphu zimenezi nthawi zambiri zimayambira mbali imodzi ya thupi la mwana, nthawi zambiri m'mutu, m'khosi kapena pachifuwa ndiyeno zimafalikira m'njira yodziwikiratu kuchokera ku mbali ina ya mitsempha kupita ku ina. Pakupita patsogolo, matendawa amatha kufalikira kumapapu, chiwindi, mafupa, mafupa kapena ziwalo zina.
Pali mtundu wosowa wa lymphoma womwe umakhala ndi mediastinal mass, umadziwika kuti primary mediastinal lalikulu B-cell lymphoma (PMBCL). Lymphoma iyi inkadziwika ngati gawo laling'ono la DLBCL koma idasinthidwanso. Mtengo PMBCL ndi pamene lymphoma imachokera ku ma cell a thymic B. Thymus ndi chiwalo cha lymphoid chomwe chili kumbuyo kwa sternum (chifuwa).
Zizindikiro zodziwika bwino za DLBCL ndi izi:
- Kutupa kopanda ululu kwa ma lymph nodes m'khosi, m'khwapa, groin kapena pachifuwa
- Kupuma pang'ono - chifukwa cha kukula kwa ma lymph nodes mu chifuwa kapena mediastinal mass
- chifuwa (nthawi zambiri chifuwa chowuma)
- kutopa
- Kuvuta kuchira ku matenda
- Kuyabwa khungu (pruritus)
B zizindikiro ndi mawu omwe amafotokoza zizindikiro zotsatirazi:
- Kutuluka thukuta usiku (makamaka usiku, komwe mungafunike kusintha zovala zawo zogona ndi zofunda)
- Kutentha thupi kosalekeza
- Kutaya kosawerengeka kosadziwika
Pafupifupi 20% ya ana omwe ali ndi DLBCL amapezeka ndi kulemera kumtunda kwa chifuwa. Izi zimatchedwa "mediastinal mass". , Kuchuluka m'chifuwa kungayambitse kupuma movutikira, chifuwa kapena kutupa kwa mutu ndi khosi chifukwa cha chotupa chopondapo pamphuno kapena mitsempha yayikulu pamwamba pa mtima.
Ndikofunika kuzindikira kuti zambiri mwazizindikirozi zimakhudzana ndi zomwe zimayambitsa zina osati khansa Izi zikutanthauza kuti lymphoma ikhoza kukhala yovuta kuti madokotala azindikire.
Kuzindikira kwa B-cell lymphoma yayikulu (DLBCL)
A biopsy Amafunikira nthawi zonse kuti adziwe kuti pali B-cell lymphoma yayikulu. A biopsy ndi ntchito kuchotsa a Lymph node kapena minofu ina yachilendo kuti muyang'ane pansi pa maikulosikopu ndi katswiri wa matenda. Biopsy nthawi zambiri imachitika pansi pa mankhwala oletsa ana kuti achepetse kupsinjika.
Nthawi zambiri, biopsy yapakati kapena excisional node biopsy ndiyo njira yabwino kwambiri yofufuzira. Izi ndikuwonetsetsa kuti madokotala atolera minofu yokwanira kuti amalize kuyezetsa koyenera kuti adziwe matenda.
Kudikirira zotsatira ikhoza kukhala nthawi yovuta. Zingakuthandizeni kulankhula ndi achibale anu, anzanu kapena namwino waluso.
Kufalikira kwa B-cell lymphoma (DLBCL)
Kamodzi a matenda wa DLBCL wapangidwa, kuyezetsa kwina kumafunika kuti awone komwe kuli m'thupi komwe kuli lymphoma. Izi zimatchedwa siteji. The kusuntha Lymphoma imathandiza dokotala kudziwa chithandizo chabwino cha mwana wanu.
Pali magawo anayi, kuyambira siteji 4 (lymphoma m'dera limodzi) mpaka siteji 1 (lymphoma yomwe ili ponseponse kapena yapamwamba).
- Gawo loyambirira amatanthauza siteji 1 ndi ma lymphoma a gawo 2. Izi zitha kutchedwanso 'localised'. Gawo 1 kapena 2 limatanthauza kuti lymphoma imapezeka m'dera limodzi kapena malo ochepa oyandikana.
- Magawo otukuka Zikutanthauza kuti lymphoma ndi sitepe 3 ndi sitepe 4, ndipo lymphoma yofala kwambiri. Nthawi zambiri, lymphoma imafalikira ku ziwalo za thupi zomwe zili kutali ndi mzake.
'Advanced' stage lymphoma imamveka, koma lymphoma ndi yomwe imadziwika kuti khansa ya m'magazi. Ikhoza kufalikira mu lymphatic system ndi minofu yapafupi. Ichi ndichifukwa chake chithandizo chamankhwala (chemotherapy) chimafunika kuchiza DLBCL.
Mayesero ofunikira angaphatikizepo:
- Mayeso a magazi (monga: kuchuluka kwa magazi, chemistry ya magazi ndi erythrocyte sedimentation rate (ESR) kuti muwone umboni wa kutupa)
- Chifuwa cha X-ray - zithunzizi zidzathandiza kuzindikira kupezeka kwa matenda pachifuwa
- Positron emission tomography (PET) scan - kuchitidwa kuti amvetsetse malo onse omwe ali ndi matenda m'thupi mankhwala asanayambe
- Scut tomography (CT) Scan
- Mafupa a mafupa amatha (nthawi zambiri zimachitika ngati pali umboni wa matenda apamwamba)
- Kupopera kwa Lumbar - Ngati lymphoma akukayikira mu ubongo kapena msana
Mwana wanunso akhoza kudwala zingapo mayeso oyambira asanayambe chithandizo chilichonse. Uku ndikuwunika magwiridwe antchito a chiwalo. Izi zikhoza kubwerezedwa panthawi komanso pambuyo pa chithandizo kuti awone ngati mankhwalawa akhudza kugwira ntchito kwa chiwalo. Mayeso ofunikira angaphatikizepo; ;
- Kufufuza mwakuthupi
- Kuwona kofunikira (kuthamanga kwa magazi, kutentha, ndi kugunda kwa mtima)
- Mtima scan
- Impso scan
- Mayesero a kupuma
- Mayeso a magazi
Ambiri mwa awa kusuntha ndi kuyezetsa ntchito ya ziwalo amachitidwanso akalandira chithandizo kuti awone ngati chithandizo cha lymphoma chagwira ntchito komanso kuwunika momwe chithandizo chakhudzira thupi.
Kuzindikira kwa B-cell lymphoma yayikulu (DLBCL)
DLBCL mwa ana ali ndi chidziwitso chabwino kwambiri (mawonekedwe). Pafupifupi ana 9 mwa 10 (90%) aliwonse amachiritsidwa atalandira mlingo mankhwala amphamvu ndi immunotherapy. Pali kafukufuku wochuluka wofuna kuchiza lymphoma iyi, ndikugogomezera kufufuza momwe mungachepetsere zotsatira zochedwa, kapena zotsatira za mankhwala oopsa omwe amatha miyezi ingapo mutalandira chithandizo.
Kupulumuka kwanthawi yayitali komanso chithandizo chamankhwala chimadalira pazinthu zingapo, kuphatikiza:
- Zaka za mwana wanu pa matenda
- Kutalika kapena gawo la khansa
- Maonekedwe a maselo a lymphoma pansi pa microscope (mawonekedwe, ntchito ndi mapangidwe a maselo)
- momwe lymphoma imayankhira chithandizo
Chithandizo cha B-cell lymphoma yofalikira
Zotsatira zonse za biopsy ndi masikanidwe akamaliza, adokotala aziwunikanso kuti asankhe chithandizo chabwino kwambiri cha mwana wanu. Kumalo ena a khansa, adokotala amakumana ndi gulu la akatswiri kuti akambirane njira yabwino kwambiri yochizira. Izi zimatchedwa a Multidisciplinary team (MDT) msonkhano.
Madokotala amaganizira zambiri zokhudza lymphoma ya mwana wanu komanso thanzi labwino kuti adziwe nthawi komanso chithandizo chomwe chikufunika. Izi zachokera pa;
- Gawo ndi kalasi ya lymphoma
- zizindikiro
- Zaka, mbiri yakale yachipatala & thanzi labwino
- Ubwino wapano wakuthupi ndi wamaganizidwe
- Zochitika Zachikhalidwe
- Zokonda zabanja
Popeza DLBCL ndi lymphoma yomwe ikukula mofulumira, imayenera kuchiritsidwa mwamsanga - nthawi zambiri mkati mwa masiku kapena masabata kuchokera ku matenda. Chithandizo cha DLBCL chimaphatikizapo kuphatikiza kwa mankhwala amphamvu ndi immunotherapy
Odwala ena omwe ali achinyamata a DLBCL amatha kuthandizidwa ndi mankhwala akuluakulu a chemotherapy omwe amatchedwa R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, & prednisolone). Izi nthawi zambiri zimatengera ngati mwana wanu akulandira chithandizo m'chipatala cha ana kapena chipatala cha akuluakulu.
Chithandizo chokhazikika cha ana oyambira DLBCL (siteji I-IIA):
- BFM-90/95: 2 - 4 kuzungulira kwa chemotherapy kutengera matenda
- Protocol mankhwala othandizira monga: cyclophosphamide, cytarabine, methotrexate, mercaptopurine, vincristine, pegaspargase, prednisolone, pirarubicin, dexamethasone.
- COG-C5961: 2 - 4 kuzungulira kwa chemotherapy kutengera matenda
Chithandizo chokhazikika cha ana a siteji yapamwamba ya DLBCL (siteji IIB-IVB):
- COG-C5961: 4 - 8 kuzungulira kwa chemotherapy kutengera matenda
- Protocol mankhwala othandizira monga: cyclophosphamide, cytarabine, doxorubicin hydrochloride, etoposide, methotrexate, prednisolone, vincristine.
- BFM-90/95: 4 - 6 kuzungulira kwa chemotherapy kutengera matenda
- Protocol mankhwala othandizira monga: cyclophosphamide, cytarabine, methotrexate, mercaptopurine, vincristine, pegaspargase, prednisolone, pirarubicin, dexamethasone.
Zotsatira zoyipa za mankhwala
Chithandizo cha DLBCL chimabwera ndi chiopsezo chokhala ndi zovuta zosiyanasiyana. Dongosolo lililonse lamankhwala limakhala ndi zotsatirapo zake ndipo dokotala yemwe akuchiza komanso/kapena namwino wodziwa za khansa akufotokozerani izi ndi mwana wanu musanayambe chithandizo.
Zina mwazotsatira zodziwika bwino za chithandizo cha B-cell lymphoma yayikulu ndi monga:
- Anemia (maselo ofiira otsika)
- Thrombocytopenia (mapulateleti otsika)
- Neutropenia (maselo oyera a magazi ochepa)
- Mseru ndi kusanza
- Mavuto am'mimba monga kudzimbidwa ndi kutsekula m'mimba
- kutopa
- Kuchepetsa chonde
Gulu lanu lachipatala, dokotala, namwino wa khansa kapena wazamankhwala, ayenera kukupatsani chidziwitso chokhudza matenda anu mankhwala, ndi wamba mavuto, ndi zizindikiro ziti zomwe munganene komanso omwe mungakumane naye. Ngati sichoncho, chonde funsani mafunso awa.
Kuteteza chonde
Mankhwala ena a lymphoma amatha kuchepetsa chonde. Izi zimatheka ndi njira zina za chemotherapy (zosakaniza za mankhwala) ndi mankhwala amphamvu kwambiri omwe amagwiritsidwa ntchito musanalowetse selo. Radiotherapy ku chiuno kumapangitsanso mwayi wochepetsa chonde. Mankhwala ena a antibody amathanso kukhudza chonde, koma izi sizodziwika bwino.
Dokotala wanu akuyenera kukulangizani ngati kubereka kungakhudzire Lankhulani ndi dokotala komanso/kapena namwino wa khansa musanayambe kulandira chithandizo ndikuyamba ngati kubereka kungakhudzire.
Kuti mudziwe zambiri kapena malangizo okhudza ana a DLBCL, chithandizo, zotsatira zake, zothandizira zomwe zilipo kapena momwe mungayendetsere chipatala, chonde lemberani chithandizo cha namwino wothandizira lymphoma pa 1800 953 081 kapena imelo yathu pa imelo nurse@lymphoma.org.au
Chisamaliro chotsatira
Mankhwala akatha, mwana wanu adzakhala ndi masikelo. Makani awa ndi owunikira momwe chithandizo chathandizira. Ma scan awonetsa madotolo momwe lymphoma yayankhira chithandizo. Izi zimatchedwa kuyankha kwamankhwala ndipo zitha kufotokozedwa ngati:
- Yankho lathunthu (CR kapena palibe zizindikiro za lymphoma) kapena a
- Kuyankha pang'ono (PR kapena pali lymphoma ilipo, koma yacheperachepera)
Mwana wanu adzafunika kutsatiridwa ndi dokotala ndikumuyendera pafupipafupi, nthawi zambiri miyezi 3-6 iliyonse. Kusankhidwa kumeneku ndi kofunikira kuti gulu lachipatala liwone momwe akuchira atalandira chithandizo. Kusankhidwa uku kumakupatsani mwayi wolankhula ndi dokotala kapena namwino zazovuta zilizonse zomwe muli nazo. Achipatala adzafuna kudziwa momwe mwana wanu ndi inu mukumvera m'thupi ndi m'maganizo, komanso kuti:
- Unikaninso mphamvu yamankhwala
- Yang'anirani zovuta zilizonse zomwe zimachitika mukalandira chithandizo
- Yang'anirani zotsatira zilizonse zochedwa mukalandira chithandizo pakapita nthawi
- Yang'anirani zizindikiro za kubwereranso kwa lymphoma
Mwana wanu nthawi zonse amakapimidwa ndi kuyezetsa magazi . Kupatulapo mwamsanga pambuyo pa chithandizo kuti awonenso momwe chithandizocho chagwirira ntchito, sikanizo nthawi zambiri sizichitika pokhapokha ngati pali chifukwa china chake. Ngati mwana wanu ali bwino, nthawi yoikidwiratu imatha kuchepa pakapita nthawi.
Kasamalidwe kobwereranso kapena kukana kwa DLBCL
Wabwereranso lymphoma ndi pamene khansa yabwerera, kutsutsa lymphoma ndi pamene khansara siimayankha mankhwala oyamba. Kwa ana ena ndi achinyamata, DLBCL imabwereranso ndipo nthawi zina sizimayankha chithandizo choyamba (refractory). Kwa odwalawa pali mankhwala ena omwe angakhale opambana, awa ndi awa:
- Mlingo waukulu wophatikiza mankhwala amphamvu otsatidwa ndi autologous stem cell transplant kapena allogeneic stem cell transplant (sioyenera anthu onse)
- Kuphatikiza chemotherapy
- immunotherapy
- Radiotherapy
- Kutenga nawo gawo pazachipatala
Pamene munthu akuganiziridwa kuti wayambiranso matenda, nthawi zambiri mayeso omwewo amachitidwa, omwe amaphatikizapo mayesero omwe atchulidwa pamwambapa. matenda ndi kusuntha gawo.
Chithandizo chikufufuzidwa
Pali mankhwala ambiri omwe akuyesedwa pano m'mayesero azachipatala padziko lonse lapansi kwa odwala omwe angopezeka kumene komanso omwe ayambiranso. Ena mwa mankhwala awa ndi awa:
- Mayesero ambiri akuphunzira kuchepetsa mbiri ya kawopsedwe ndi zotsatira zochedwa za mankhwala a chemotherapy
- Chithandizo cha CAR T-cell
- Copanlisib (ALIQOPATM - PI3K inhibitor)
- Venetoclax (VENCLEXTATM - BCL2 inhibitor)
- Temsirolimus (TORISOLTM)
- CUDC-907 (novel targeting therapy)
Kodi chimachitika ndi chiyani mukalandira chithandizo?
Zotsatira mochedwa
Nthawi zina zotsatira za mankhwala zingapitirire kapena kukula miyezi kapena zaka chithandizo chitatha. Izi zimatchedwa zotsatira mochedwa. Kuti mudziwe zambiri, pitani ku gawo la 'late effects' kuti mudziwe zambiri za zotsatira zoyambilira komanso mochedwa zomwe zingachitike kuchokera kumankhwala a lymphoma.
Ana ndi achinyamata akhoza kukhala ndi zotsatira zokhudzana ndi mankhwala zomwe zingawoneke miyezi kapena zaka pambuyo pa chithandizo, kuphatikizapo mavuto ndi kukula kwa mafupa ndi kukula kwa ziwalo zogonana mwa amuna, kusabereka, ndi chithokomiro, matenda a mtima ndi mapapo. Njira zambiri zochiritsira zamakono ndi kafukufuku wofufuza tsopano akuyang'ana kuyesa kuchepetsa chiopsezo cha zotsatira zochedwa izi.
Pazifukwa izi ndikofunikira kuti opulumuka a B-cell lymphoma (DLBCL) alandire kutsata ndikuwunika pafupipafupi.
