Kufotokozera mwachidule Burkitt Lymphoma
Burkitt lymphoma ndi mtundu woopsa kwambiri wa lymphoma, ndipo umaganiziridwa kuti ndi khansa yomwe ikukula mofulumira kwambiri - kapena mtundu woopsa kwambiri wa khansa.
Chifukwa chakuti imayamba ndikufalikira mofulumira kwambiri, imayenera kuthandizidwa ndi chemoimmunotherapy mofulumira kwambiri pambuyo pozindikira. Komabe, chifukwa chemotherapy imagwira ntchito bwino pama cell omwe akukula mwachangu, imakhudza kwambiri kuwononga ma cell a Burkitt Lymphoma.
Anthu ambiri omwe ali ndi Burkitt Lymphoma amatha kuchiritsidwa.
Kumvetsetsa B-cell lymphocytes
Burkitt Lymphoma ndi khansa ya B-cell lymphocytes, kotero kuti mumvetse Burkitt Lymphoma muyenera kudziwa pang'ono za ma B-Cell lymphocytes anu.
B-cell lymphocytes:
- Ndi mtundu wa maselo oyera a magazi.
- Menyani matenda ndi matenda kuti mukhale athanzi.
- Kumbukirani matenda omwe mudakhala nawo m'mbuyomu, kotero ngati mutatenganso matenda omwewo, chitetezo chamthupi chanu chingathe kulimbana nacho moyenera komanso mwachangu.
- Amapangidwa m'mafupa anu (gawo la spongy pakati pa mafupa anu), koma nthawi zambiri amakhala mu ndulu ndi ma lymph nodes anu. Ena amakhala mu thymus ndi magazi anunso.
- Mutha kuyenda kudzera m'mitsempha yanu kupita ku gawo lililonse la thupi lanu kukalimbana ndi matenda kapena matenda.
Burkitt Lymphoma imayamba pamene ena mwa B-maselo anu amakhala ndi khansa. Amakula mosalamulirika, siabwinobwino, ndipo samafa pa nthawi yoyenera.
Mukakhala ndi Burkitt Lymphoma, ma lymphocyte anu a khansa a B-cell:
- Kulani ndi kuchulukitsa mofulumira kwambiri.
- Sizigwira ntchito moyenera polimbana ndi matenda ndi matenda.
- Yang'anani ndikuchita mosiyana kwambiri ndi ma B-cell anu athanzi.
- Zingayambitse lymphoma kukula ndikukula m'madera ambiri a thupi lanu.
Mitundu ya Burkitt Lymphoma
Pali mitundu yosiyanasiyana ya lymphoma. Dinani pamitu yomwe ili pansipa kuti mudziwe zamitundu yosiyanasiyana.
Burkitt Lymphoma, yomwe imapezeka kwambiri mwa anthu a ku Africa, ndipo ndi lymphoma yofala kwambiri mwa ana a ku Africa. Zimapezekanso kwambiri mwa anthu omwe ali ndi malungo kapena kachilombo ka Epstein-Barr (EBV).
Endemic Burkitt Lymphoma nthawi zambiri imayambira m'nsagwada mwako, kapena pamafupa ena a nkhope yanu, komanso imatha kuyambika m'mimba mwako (m'mimba).
Burkitt Lymphoma ya Sporadic imatha kuchitika kudera lililonse la dziko lapansi ndipo monga momwe ma lymphoma ambiri amaganiziridwa kuti amapezeka kwambiri mwa anthu omwe ali ndi kachilombo ka Epstein-Barr. Nthawi zambiri zimayambira m'mimba mwako, kotero zimatha kukhala zowawa kapena kusamva bwino m'mimba mwako.
Sporadic Burkitt Lymphoma ikhoza kufalikira ku dongosolo lanu lapakati la mitsempha, kuphatikizapo ubongo wanu ndi msana, chithokomiro chanu, tonsils ndi mafupa a nkhope yanu.
Immunodeficiency-associated Burkitt Lymphoma imapezeka kwambiri mwa anthu omwe ali ndi chitetezo chamthupi chofooka, ndipo amapezeka mwa anthu omwe ali ndi kachilombo ka HIV (HIV) kapena omwe apeza matenda a AIDS (AIDS).
Komabe, subtype iyi imathanso kukula ngati mumwa mankhwala omwe amakupangitsani chitetezo chamthupi monga omwe amamwedwa pambuyo poika chiwalo kapena ngati muli ndi matenda a autoimmune.
Kodi Burkitt Lymphoma ndi yochuluka bwanji?
Burkitt lymphoma imakhudza anthu a msinkhu uliwonse, kuphatikizapo ana ndi akuluakulu. Ndi mtundu wa lymphoma wofala kwambiri mwa ana azaka zapakati pa 5 ndi 10 ndipo umapanga 30% mwa ana onse omwe ali ndi lymphoma - kutanthauza kuti ana atatu mwa khumi aliwonse omwe ali ndi lymphoma adzakhala ndi Burkitt Lymphoma.
Ndizosowa kwambiri mwa akulu omwe ali ndi wamkulu mmodzi kapena awiri mwa 1 (2-100%) omwe ali ndi lymphoma yokhala ndi Burkitt Lymphoma. Kwa akuluakulu, amapezeka kwambiri mwa anthu azaka zapakati pa 1-2.
Zizindikiro za Lymphoma
Zizindikiro zina za Burkitt lymphoma ndizofanana ndi zizindikiro za ma lymphoma ena, ndipo zina zingakhale zokhudzana ndi kumene lymphoma ikukula.
Malo omwe amapezeka Burkitt Lymphoma angapezeke ndi awa:
- ma lymph nodes m'khosi mwanu, m'khwapa ndi m'chiuno
- mimba yanu ndi matumbo anu
- dongosolo lanu lapakati lamanjenje (CNS) - ubongo ndi msana
- fupa la fupa
- ndulu, chiwindi ndi ziwalo zina za thupi lanu
- nsagwada zanu kapena mafupa ena pankhope panu.
Nodal ndi owonjezera nodal Burkitt Lymphoma
Burkitt Lymphoma imatha kuyamba m'malo am'magazi anu kapena kunja kwa ma lymph nodes anu. Ikayamba m'mitsempha yanu imatchedwa "nodal". Zikayamba kunja kwa ma lymph nodes - monga m'ziwalo zanu kapena m'mafupa zimatchedwa "zowonjezera".
Chizindikiro chodziwika bwino cha nodal Burkitt Lymphoma ndi kutupa kwa ma lymph nodes omwe amatha kuchitika mbali iliyonse ya thupi lanu. Amamveka kwambiri m'khosi, m'khwapa kapena m'chiuno, chifukwa ma lymph nodes ali pafupi ndi khungu lanu.
Koma timakhalanso ndi ma lymph nodes pachifuwa, pamimba, mikono, miyendo ndi mutu. Chifukwa Burkitt Lymphoma imakula ndikufalikira mwachangu mutha kuwona ma lymph node m'malo ambiri athupi lanu akuyamba kutupa.
Zizindikiro zina za kutupa kwa ma lymph nodes kapena extranodal lymphoma
Kutengera ndi mbali ziti za thupi lanu zomwe zatupa ma lymph nodes mutha kukhala ndi zizindikiro zosiyanasiyana. Ma lymph nodes ambiri otupa okhudzana ndi lymphoma sakhala opweteka, koma amatha kukhala opweteka ngati akakamiza ziwalo zina, minyewa kapena ngati atakula kwambiri.
Kuphatikiza pa ma lymph nodes, timakhalanso ndi minofu ya lymphoid m'madera osiyanasiyana a matupi athu monga m'kamwa, m'mimba, m'matumbo, m'mapapu. Minofu ya Lymphoid ndi madera a maselo a chitetezo cha mthupi omwe amakhala m'madera a matupi athu kuti ayang'ane ndikumenyana ndi matenda. Burkitt Lymphoma imathanso kuyambitsa kapena kufalikira kumadera aliwonsewa.
Zizindikiro zingaphatikizepo izi.
Dera lomwe lakhudzidwa | zizindikiro |
Chifuwa kapena khosi | Kupuma pang'ono Kusintha kwa mawu anu Chifuwa chosalekeza Ululu, kupanikizika kapena kusapeza bwino pachifuwa kapena khosi Kusintha kwa rhythm ya mtima ngati kupanikizika kuli pamtima wanu |
Chapakati mantha dongosolo (Ubongo, msana ndi dera kumbuyo kwa maso anu) | Kusokonezeka kapena kukumbukira kusintha chizungulire Kusintha kwa masomphenya anu Kufooka, kuyabwa kapena kuyaka Kuvuta kuyenda Kuvuta kupita kuchimbudzi Zovuta (zokwanira) Kusintha kwa umunthu |
M'matumbo - (Pakamwa, m'mimba ndi matumbo) | Mseru ndi kusanza kapena popanda Kutsekula m'mimba kapena kudzimbidwa Mimba yotupa (mutha kuwoneka ngati muli ndi pakati) Magazi mukapita kuchimbudzi Kukhuta ngakhale simunadye, kapena kudya pang'ono Zovuta kumeza. |
Bone Marrow | Kusintha kwa kuchuluka kwa magazi anu abwino kuphatikiza:
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Ziwalo za lymphatic system yanu - ndulu ndi thymus
Mphuno yanu ndi chiwalo chomwe chimasefa magazi anu ndikukhala athanzi. Ndilinso chiwalo cha ma lymphatic system komwe ma B-cell lymphocyte amakhala ndikupanga ma antibodies kuti athe kulimbana ndi matenda. Ili kumanzere kwa mimba yanu yakumtunda pansi pa mapapo anu komanso pafupi ndi mimba yanu (mimba).
Mphuno yanu ikakula kwambiri, imatha kukupanikizani m'mimba ndikukupangitsani kumva kuti mwakhuta, ngakhale simunadye kwambiri. Mukhozanso kupeza:
- Magazi otsika.
- Kutopa kwambiri.
- Kuchepetsa thupi.
- Jaundice (khungu ndi maso achikasu).
- Ululu m'mimba mwako kapena kumverera kwa "bloating".
Anu thymus ndi gawo la lymphatic system yanu. Ndi chiwalo chooneka ngati gulugufe chomwe chimakhala kuseri kwa fupa la chifuwa chanu kutsogolo kwa chifuwa chanu. Ma cell ena a B amakhalanso ndikudutsa mu thymus. Ngati lymphoma ili mu thymus mukhoza kukhala ndi chotupa pachifuwa chanu taht akhoza kukakamiza ziwalo zina pachifuwa chanu. Zizindikiro zimatha kukhala zofanana ndi zomwe zalembedwa patebulo pamwambapa.
Chiwindi
- Jaundice.
- Ululu kapena kusapeza bwino komwe kumawonekera mpaka paphewa lakumanzere.
- Kutaya njala ndi kuonda.
- Kutupa kwa m'mimba mwako chifukwa cha kuchuluka kwamadzimadzi (ascites).
- Kutuluka magazi kwachilendo.
B-zizindikiro
B-zizindikiro zikhoza kuchitika pamene lymphoma ikukula mwachangu. Zitha kusonyeza kuti lymphoma ikugwiritsa ntchito mphamvu zanu zosungiramo mphamvu kapena ikupanga mankhwala omwe amakhudza momwe thupi lanu limayendera kutentha kwanu. Nthawi zonse perekani zizindikiro za B kwa dokotala wanu.
Kuzindikira ndi Kukhazikika kwa Burkitt Lymphoma
Ngati dokotala akuganiza kuti muli ndi lymphoma, ayenera kukonzekera mayesero angapo ofunikira. Mayeserowa amafunikira kuti atsimikizire kapena kuchotsa lymphoma monga chifukwa cha zizindikiro zanu.
Kuti muzindikire Burkitt Lymphoma mufunika biopsy. Biopsy ndi njira yochotsera gawo, kapena ma lymph node onse omwe akhudzidwa ndi / kapena sampuli ya m'mafupa. Kenako biopsy imafufuzidwa ndi asayansi mu labotale kuti awone ngati pali zosintha zomwe zimathandiza dokotala kuzindikira matenda a Burkitt.
Mukakhala ndi biopsy, mutha kukhala ndi mankhwala am'deralo kapena onse. Izi zidzatengera mtundu wa biopsy ndi gawo la thupi lanu lomwe latengedwa. Pali mitundu yosiyanasiyana ya biopsies ndipo mungafunike kuposa imodzi kuti mupeze zitsanzo zabwino kwambiri.
Mayeso a magazi
Kuyezetsa magazi kumayesedwa poyesa kufufuza lymphoma yanu, komanso panthawi yonse ya chithandizo chanu kuti muwonetsetse kuti ziwalo zanu zikugwira ntchito bwino ndipo zingathe kupirira chithandizo chathu.
Core kapena finene singano biopsy
Ma core biopsies a singano amatengedwa kuti achotse chitsanzo cha lymph node yotupa kapena chotupa kuti awone ngati pali zizindikiro za lymphoma.
Dokotala wanu nthawi zambiri amagwiritsa ntchito mankhwala ochititsa dzanzi kuti asamve ululu panthawi ya ndondomekoyi, koma mudzakhala maso panthawiyi. Kenako amaika singano mu lymph node yotupa kapena chotupa ndikuchotsa chitsanzo cha minofu.
Ngati kutupa kwa lymph node kapena chotupa chili mkati mwa thupi lanu, biopsy ikhoza kuchitidwa mothandizidwa ndi ultrasound kapena chidziwitso cha x-ray (imaging).
Mutha kukhala ndi mankhwala oletsa ululu wa izi (zomwe zimakupangitsani kugona kwakanthawi). Mukhozanso kukhala ndi zingwe zingapo pambuyo pake.
Ma core singano biopsy amatenga zitsanzo zazikulu kuposa biopsy yabwino ya singano.
Excisional node biopsy
Excisional node biopsies imachitika pamene lymph node yanu yotupa kapena chotupa chili chozama kwambiri m'thupi mwanu kuti musafikiridwe ndi pachimake kapena singano. Mudzakhala ndi mankhwala oletsa ululu omwe amakupangitsani kugona kwakanthawi kuti mukhale chete, osamva kupweteka.
Panthawiyi, dokotala wa opaleshoni amachotsa lymph node kapena chotupa chonse ndikuchitumiza ku pathology kuti akayesedwe.
Mudzakhala ndi chilonda chaching'ono chokhala ndi zingwe zochepa, ndi kuvala pamwamba.
Stitches nthawi zambiri amakhala kwa masiku 7-10, koma adokotala kapena namwino wanu adzakupatsani malangizo amomwe mungasamalire mavalidwe, ndi nthawi yobwerera kuti mukasokere.
Burkitt Lymphoma Kuzindikira
Dokotala wanu akapeza zotsatira kuchokera kwa inu kuyezetsa magazi ndi biopsies adzatha kukuuzani ngati muli ndi Burkitt Lymphoma ndipo akhoza kukuuzani kuti muli ndi mtundu wanji wa Burkitt. Adzafunanso kuyesa mayesero ambiri kuti ayambe ndikuyesa lymphoma yanu.
Kusanthula ndi Kuwerengera Burkitt Lymphoma
Mukapezeka ndi Burkitt Lymphoma, dokotala wanu adzakhala ndi mafunso ambiri okhudza lymphoma yanu. Izi ziphatikizapo:
- Kodi lymphoma yanu ndi gawo liti?
- Ndi mtundu wanji wa Burkitt womwe muli nawo?
Dinani pamitu ili m'munsiyi kuti mudziwe zambiri za masanjidwe ndi masanjidwe.
Kuwerengera kumatanthawuza kuchuluka kwa thupi lanu lomwe limakhudzidwa ndi lymphoma yanu - kapena, momwe yafalikira kuchokera pomwe idayambira.
B-maselo amatha kupita ku gawo lililonse la thupi lanu. Izi zikutanthauza kuti ma cell a lymphoma (ma cell a khansa B), amathanso kupita ku gawo lililonse la thupi lanu. Mudzafunika kuyesanso kuti mupeze zambiri. Mayesowa amatchedwa staging test ndipo mukapeza zotsatira, mupeza ngati muli ndi siteji yoyamba (I), siteji yachiwiri (II), gawo lachitatu (III) kapena gawo lachinayi (IV) Burkitt Lymphoma. Komabe, chifukwa Burkitt ndi wovuta kwambiri, nthawi zambiri imakhala yopita patsogolo (gawo 3 kapena 4) mukapezeka,
Gawo lanu la lymphoma lidzadalira:
- Ndi madera angati a thupi lanu omwe ali ndi lymphoma
- Kumene lymphoma imaphatikizapo ngati ili pamwamba, pansi kapena mbali zonse za diaphragm (minofu yaikulu, yooneka ngati dome pansi pa nthiti yomwe imalekanitsa chifuwa ndi mimba yanu)
- Kaya lymphoma yafalikira ku mafupa anu kapena ziwalo zina monga chiwindi, mapapo, khungu kapena fupa.
Gawo XNUMX ndi lachiwiri limatchedwa 'gawo loyambirira kapena lochepa' (lokhala ndi gawo laling'ono la thupi lanu).
Gawo III ndi IV limatchedwa 'advanced stage' (lofalikira kwambiri).
Gawo 1 | dera limodzi la lymph node limakhudzidwa, kaya pamwamba kapena pansi pa diaphragm * |
Gawo 2 | madera awiri kapena angapo a ma lymph node amakhudzidwa mbali imodzi ya diaphragm * |
Gawo 3 | Malo ochepera a lymph node m'mwamba ndi gawo limodzi la m'munsi mwa diaphragm* amakhudzidwa |
Gawo 4 | Lymphoma ili mu ma lymph nodes angapo ndipo yafalikira kumadera ena a thupi (monga mafupa, mapapo, chiwindi). |
Zowonjezera masiteji
Dokotala wanu anganenenso za siteji yanu pogwiritsa ntchito kalata, monga A, B, E, X kapena S. Makalatawa amapereka zambiri zokhudza zizindikiro zomwe muli nazo kapena momwe thupi lanu likukhudzidwira ndi lymphoma. Zonsezi zimathandiza dokotala wanu kupeza ndondomeko yabwino yothandizira inu.
Letter | kutanthauza | Importance |
A kapena B |
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E ndi X |
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S |
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(Nyendo yanu ndi chiwalo cha m'mitsempha yanu yomwe imasefa ndikuyeretsa magazi anu, ndipo ndi malo omwe B-maselo anu amapumula ndikupanga ma antibodies) |
Mayeso a masiteji
Kuti mudziwe kuti muli ndi gawo liti, mutha kufunsidwa kuti muyese ena mwa magawo awa:
Scut tomography (CT) Scan
Makani awa amatenga zithunzi za mkati mwa chifuwa, mimba kapena chiuno. Amapereka zithunzi zatsatanetsatane zomwe zimapereka zambiri kuposa X-ray wamba.
Positron emission tomography (PET) scan
Ichi ndi jambulani chomwe chimajambula zithunzi za mkati mwa thupi lanu lonse. Mudzapatsidwa ndi singano ndi mankhwala omwe maselo a khansa - monga maselo a lymphoma amayamwa. Mankhwala omwe amathandiza PET scan kudziwa komwe lymphoma ili ndi kukula kwake ndi mawonekedwe ake powunikira malo omwe ali ndi maselo a lymphoma. Maderawa nthawi zina amatchedwa "otentha".
Kupopera kwa Lumbar
Kuphulika kwa lumbar ndi njira yomwe imachitidwa kuti muwone ngati muli ndi lymphoma yanu dongosolo lalikulu la mitsempha (CNS), zomwe zimaphatikizapo ubongo wanu, msana ndi malo ozungulira maso anu. Muyenera kunena mwakachetechete kwambiri panthawi ya opaleshoniyo, kotero kuti makanda ndi ana akhoza kupatsidwa mankhwala opha ululu kuti awagone kwa kanthawi kochepa. Akuluakulu ambiri amangofunika mankhwala ochititsa dzanzi m'deralo.
Dokotala wanu amalowetsa singano kumbuyo kwanu, ndikutulutsa madzi pang'ono otchedwa "cerebral spinal fluid” (CSF) kuchokera kuzungulira msana wanu. CSF ndi madzimadzi omwe amagwira ntchito ngati chotsitsa ku CNS yanu. Imanyamulanso mapuloteni osiyanasiyana ndi matenda olimbana ndi ma cell a chitetezo chamthupi monga ma lymphocyte kuti ateteze ubongo wanu ndi msana. CSF ingathandizenso kukhetsa madzi owonjezera omwe mungakhale nawo muubongo wanu kapena kuzungulira msana wanu kuti mupewe kutupa m'malo amenewo.
Zitsanzo za CSF zidzatumizidwa ku matenda ndi kufufuzidwa ngati pali zizindikiro za lymphoma.
Mafupa a mafupa amatha
- Bone marrow aspirate (BMA): mayesowa amatenga madzi pang'ono omwe amapezeka mu fupa la mafupa.
- Bone marrow aspirate trephine (BMAT): mayesowa amatenga chitsanzo chaching'ono cha minofu ya mafupa.
Zitsanzozo zimatumizidwa ku pathology komwe amakawona ngati pali zizindikiro za lymphoma.
Njira yopangira ma biopsies a m'mafupa imatha kusiyana kutengera komwe mukumwa mankhwala, koma nthawi zambiri imaphatikizapo mankhwala ogonetsa am'deralo kuti athetse vutolo.
M'zipatala zina, mutha kupatsidwa mankhwala opepuka omwe amakuthandizani kuti mupumule ndipo angakulepheretseni kukumbukira njirayo. Komabe anthu ambiri safuna izi ndipo m'malo mwake akhoza kukhala ndi "mluzu wobiriwira" woti aziyamwa. Mluzu wobiriwirawu uli ndi mankhwala opha ululu mmenemo (otchedwa Penthrox kapena methoxyflurane), omwe mumagwiritsa ntchito pakufunika nthawi yonseyi.
Onetsetsani kuti mufunse dokotala zomwe zilipo kuti mukhale omasuka panthawi ya ndondomekoyi, ndipo kambiranani nawo zomwe mukuganiza kuti zingakhale zabwino kwambiri kwa inu.
Zambiri za biopsies ya m'mafupa zitha kupezeka patsamba lathu Pano.
Burkitt Lymphoma ndi khansa yoopsa kwambiri ya lymphoma komanso khansa yoopsa kwambiri. Choncho, nthawi zonse amaonedwa kuti ndi lymphoma yapamwamba.
Gululi limatanthawuza momwe maselo akuchulukira mwachangu, momwe amawonekera komanso momwe amachitira.
Maselo a lymphoma apamwamba amachulukana mofulumira kwambiri, amawoneka mosiyana kwambiri ndi ma B-cell lymphocyte anu ndipo sangathe kugwira ntchito momwe ma lymphocyte ayenera kugwirira ntchito.
Chiwopsezo chochepa komanso Chiwopsezo chachikulu cha Burkitt Lymphoma
Dokotala wanu atha kunenanso za Burkitt wanu ngati chiopsezo chachikulu kapena chochepa. Izi ndizowonjezera zomwe amagwiritsa ntchito kuti adziwe chithandizo chomwe chili choyenera kwa inu. Chiwopsezo chanu chidzatsimikiziridwa potengera izi:
- Kaya muli ndi lymphoma m'kati mwa mitsempha yanu (CNS).
- Ngati mayeso a magazi anu akuwonetsa kuchuluka kwa lactate dehydrogenase (LDH).
- Ngati muli ndi ma genetic rearrangements kapena kusintha.
Kuyesa kwa cytogenetic
Mayesero a Cytogenetic amachitidwa kuti ayang'ane kusiyana kwa majini omwe angakhale nawo pa matenda anu. Kuti mumve zambiri pa izi chonde onani gawo lathu pakumvetsetsa chibadwa chanu cha lymphoma patsamba lino. Mayesero omwe amagwiritsidwa ntchito poyang'ana kusintha kwamtundu uliwonse amatchedwa cytogenetic tests. Mayesowa amayang'ana kuti awone ngati mwasintha ma chromosome ndi majini.
Nthawi zambiri timakhala ndi ma chromosomes 23, ndipo amawerengedwa molingana ndi kukula kwake. Mukakhala ndi Burkitt Lymphoma, ma chromosome anu amatha kuwoneka mosiyana.
Kodi majini ndi ma chromosome ndi chiyani
Selo lililonse lomwe limapanga thupi lathu limakhala ndi phata, ndipo mkati mwa phata muli ma chromosomes 23. Chromozomu iliyonse imapangidwa kuchokera ku DNA (deoxyribonucleic acid) yomwe ili ndi chibadwa chathu. Majini athu amapereka malamulo ofunikira kuti apange maselo onse ndi mapuloteni m'thupi lathu, ndipo amawauza momwe angawonekere kapena kuchita.
Ngati pali kusintha (kusintha) m'ma chromosome kapena majini, mapuloteni ndi maselo anu sangagwire ntchito bwino.
Ma lymphocyte amatha kukhala maselo a lymphoma chifukwa cha kusintha kwa majini (kutchedwa masinthidwe kapena kusintha) mkati mwa maselo. Lymphoma biopsy yanu ikhoza kuyang'aniridwa ndi katswiri wazachipatala kuti awone ngati muli ndi masinthidwe amtundu uliwonse.
Kusamukira ku Burkitt Lymphoma
Ku Burkitt Lymphoma mudzakhala ndi kusintha kwa majini anu otchedwa translocation. Izi zimachitika pamene kachigawo kakang’ono ka ma chromosome aŵiri asinthana malo. Jini yomwe nthawi zonse imakhudza Burkitt Lymphoma imaphatikizapo jini ya MYC pa chromosome yachisanu ndi chitatu pomwe kusamutsidwa kumachitika ndi jini pa 8th chromosome. Mudzaona zolembedwa ngati t(14:8).
Chithandizo cha Burkitt Lymphoma
Zotsatira zanu zonse kuchokera ku biopsy, kuyezetsa kwa cytogenetic ndi masikanidwe akamaliza, adokotala aziwunikanso izi kuti asankhe chithandizo chabwino kwambiri chomwe mungachithandizire. Kumalo ena a khansa, dokotala amakumananso ndi gulu la akatswiri kuti akambirane njira yabwino kwambiri yochizira. Izi zimatchedwa a Multidisciplinary team (MDT) msonkhano.
Dokotala wanu adzaganizira zambiri za Burkitt Lymphoma yanu, koma muyenera kuyamba chithandizo ndi chemo-immunotherapy mwamsanga mutazindikira. Popanda chithandizo Burkitt Lymphoma imapha, komabe ndi chithandizo pali mwayi wabwino kwambiri wochiritsidwa.
Chemo-immunotherapy amatanthauza kukhala ndi mankhwala otchedwa chemotherapy ndi monoclonal antibody. Ma antibodies a monoclonal nthawi zambiri amatchedwa immunotherapy chifukwa amathandizira chitetezo cha mthupi kulimbana ndi khansa. Chemotherapy imagwira ntchito poukira mwachindunji ma cell omwe akukula mwachangu.
Zinthu zina zomwe dokotala angaganizire pokonzekera chithandizo chanu ndi monga:
- munthu siteji ya lymphoma, kusintha kwa majini ndi zizindikiro
- zaka, mbiri yakale yachipatala ndi thanzi labwino
- umoyo wakuthupi ndi wamaganizo ndi zokonda za odwala
- zizindikiro zilizonse zomwe mukupeza.
Mayesero ena
Mayesero ochulukirapo atha kulamulidwa musanayambe chithandizo kuti mutsimikizire kuti mtima wanu, mapapo ndi impso zimatha kuthana ndi mankhwalawa. Izi zingaphatikizepo ECG (electrocardiogram), kuyesa ntchito yamapapu kapena kusonkhanitsa mkodzo wa maola 24.
Dokotala wanu kapena namwino wa khansa akhoza kukufotokozerani dongosolo lanu la chithandizo ndi zotsatira zake, ndipo alipo kuti ayankhe funso lililonse lomwe mungakhale nalo. Ndikofunika kuti mufunse dokotala wanu ndi/kapena namwino wa khansa mafunso pa chilichonse chomwe simukuchidziwa.
Mukhozanso kuyimbira foni kapena kutumiza imelo ku Lymphoma Australia Namwino Helpline ndi mafunso anu ndipo titha kukuthandizani kuti mudziwe zolondola.
Namwino wa namwino wa Lymphoma:
Foni: 1800 953 081
Email: nurse@lymphoma.org.au
Mafunso oti mufunse dokotala musanayambe chithandizo
Zingakhale zovuta kudziwa mafunso oyenera kufunsa pamene mukuyamba kulandira chithandizo. Ngati simukudziwa, zomwe simudziwa, mungadziwe bwanji zomwe mungafunse?
Kukhala ndi chidziwitso choyenera kungakuthandizeni kudzidalira komanso kudziwa zomwe mungayembekezere. Zingakuthandizeninso kukonzekera pasadakhale zomwe mungafunike.
Talemba mndandanda wa mafunso omwe mungawapeze kukhala othandiza. Zoonadi, mkhalidwe wa aliyense ngwosiyana, chotero mafunso ameneŵa samakhudza chirichonse, koma amapereka chiyambi chabwino.
Dinani ulalo womwe uli pansipa kuti mutsitse PDF yosindikizidwa ya mafunso kwa dokotala wanu.
Kuteteza Chonde
Chithandizo cha Burkitt Lymphoma chingakhudze chonde chanu (kutha kukhala ndi ana). Izi zikhoza kuchitika kwa akuluakulu ndi ana, amuna ndi akazi. Ngati inu (kapena mwana wanu) mukufuna kukhala ndi ana m'tsogolomu, lankhulani ndi dokotala wanu ngati chonde chanu chingatetezedwe mtsogolo.
Ma Protocol Odziwika Othandizira Akuluakulu Omwe Ali ndi Burkitt Lymphoma
Mankhwala anu nthawi zambiri amagwira ntchito bwino motsutsana ndi lymphoma yanu, koma amathanso kukhudza maselo anu abwino. Chifukwa chake pamafunika nthawi kuti ma cell anu abwino achire. Maselo athanzi amabwerera mwachangu kuposa ma cell a lymphoma chifukwa amakhala okonzeka kwambiri.
Ma protocol ochiritsira omwe mungapatsidwe ndi awa:
DA-R-EPOCH (Mlingo wosinthidwa wa rituximab, etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin)
R-CODOX-M (rituximab, cyclophosphamide, vincristine, doxorubicin, methotrexate)
- R-CODOX-M imasinthidwa ndi Chithunzi cha R-IVAC (rituximab, ifosfamide, etoposide, cytarabine)
GMALL 2002 (odwala opitilira zaka 55)
GMALL 2002 (odwala osakwana zaka 55)
Hyper CVAD gawo A
- Hyper CVAD gawo A limasinthidwa ndi Hyper CVAD Gawo B
Ma Protocol Odziwika Othandizira Ana Omwe Ali ndi Burkitt Lymphoma
- R-COPADM: rituximab, cyclophosphamide, vincristine, methotrexate, cytarabine, Prednisolone, doxorubicin, etoposide.
- KUSINTHA LMB89: cyclophosphamide, vincristine, methotrexate, doxorubicin), cytarabine, etoposide.
Kusiyana kwina kwa ma protocol a chemotherapy omwe amagwiritsidwa ntchito pa ana a Burkitt lymphoma ndi awa:
- CHOP: cyclophosphamide, daunorubicin, vincristine ndi prednisolone
- COPAD: cyclophosphamide, cytarabine, doxorubicin, vincristine, etoposide, Prednisolone.
- COPADM: cyclophosphamide, methotrexate, cytarabine, doxorubicin, vincristine, etoposide.
Kubwereranso kapena Refractory Burkitt Lymphoma
Nthawi zina, lymphoma yanu singayankhe pamzere woyamba wamankhwala omwe muli nawo. Izi zikachitika, lymphoma yanu imatchedwa refractory.
Nthawi zina, mutha kupeza yankho labwino kuchokera kumankhwala anu, koma lymphoma imatha kubwereranso (kubwerera) pakapita nthawi.
Kwa Burkitt Lymphoma yomwe yayambanso komanso yobwereranso mudzapatsidwa chithandizo chochulukirapo.
Kuchiza mumzere wachiwiri kapena wachitatu kungaphatikizepo:
- immuno-chemotherapy kwambiri
- kusambira maselo
- Chithandizo cha CAR T-cell
Kuti mumve zambiri zamankhwala ndi zinthu zomwe mungaganizire onani tsamba lathu lamankhwala.
Zovuta zachipatala
Ndibwino kuti nthawi iliyonse yomwe mukufuna kuyamba mankhwala atsopano mumafunsa dokotala za mayesero a zachipatala omwe mungakhale oyenerera.
Mayesero azachipatala ndi ofunikira kuti apeze mankhwala atsopano, kapena mankhwala osakanikirana kuti apititse patsogolo chithandizo cha Burkitt Lymphoma. mtsogolomu.
Akhozanso kukupatsani mwayi woyesera mankhwala atsopano, mankhwala osakaniza kapena mankhwala ena omwe simungathe kupita nawo kunja kwa mayesero. Ngati mukufuna kutenga nawo mbali pamayesero azachipatala, funsani dokotala kuti ndi mayesero ati azachipatala omwe mukuyenera nawo.
Pali mankhwala ambiri komanso kuphatikiza kwatsopano kwamankhwala omwe akuyesedwa pano m'mayesero azachipatala padziko lonse lapansi kwa odwala omwe ali ndi matenda a Burkitt Lymphoma omwe angopezeka kumene komanso oyambiranso.
Kuneneratu kwa Burkitt Lymphoma - ndi zomwe zimachitika mankhwala akatha
Kuneneratu ndi mawu omwe amagwiritsidwa ntchito pofotokoza njira yomwe ingatheke matenda anu, momwe angayankhire chithandizo ndi momwe mungachitire panthawi ya chithandizo ndi pambuyo pake.
Pali zinthu zambiri zomwe zimapangitsa kuti mukhale ndi matenda anu ndipo sizingatheke kufotokoza zonse zokhudzana ndi matenda. Komabe, Burkitt Lymphoma nthawi zambiri imayankha bwino chithandizo ndipo odwala ambiri omwe ali ndi khansara amatha kuchiritsidwa - kutanthauza kuti mutalandira chithandizo, palibe chizindikiro cha Burkitt Lymphoma m'thupi lanu. Komabe, pali kagulu kakang'ono ka anthu omwe sangayankhe bwino pa chithandizo.
Zinthu zomwe zingakhudze prognosis
Zina mwazinthu zomwe zingakhudze kuneneratu kwanu ndi izi:
- Mumakalamba komanso thanzi lanu lonse panthawi ya matenda.
- Momwe mumayankhira chithandizo.
- Bwanji ngati ma genetic masinthidwe muli nawo.
- Gulu laling'ono la Burkitt Lymphoma lomwe muli nalo.
Ngati mukufuna kudziwa zambiri za matenda anu, chonde lankhulani ndi katswiri wa hematologist kapena oncologist. Adzatha kukufotokozerani zomwe zingakuwopsezeni komanso zomwe zikukuchitikirani.
Kupulumuka - Kukhala ndi, komanso pambuyo pa khansa
Kukhala ndi moyo wathanzi, kapena kusintha kwa moyo wabwino mukalandira chithandizo kungathandize kwambiri kuti muchiritsidwe. Pali zinthu zambiri zomwe mungachite kuti mukhale ndi moyo wabwino pambuyo pa Burkitt.
Anthu ambiri amapeza kuti atapezeka ndi khansa, kapena kulandira chithandizo, zolinga zawo ndi zomwe amaika patsogolo pamoyo wawo zimasintha. Kudziwa ‘zachilendo’ zanu kungatenge nthawi komanso kukukhumudwitsani. Zoyembekeza za banja lanu ndi anzanu zingakhale zosiyana ndi zanu. Mutha kudzimva kukhala osungulumwa, kutopa kapena kuchuluka kwa malingaliro osiyanasiyana omwe angasinthe tsiku lililonse.
Zolinga zazikulu pambuyo pa chithandizo cha lymphoma yanu ndi kukhalanso ndi moyo ndipo:
- khalani okangalika momwe mungathere pantchito yanu, banja lanu, ndi maudindo ena amoyo wanu
- kuchepetsa zotsatira ndi zizindikiro za khansa ndi chithandizo chake
- zindikirani ndikuwongolera zovuta zilizonse mochedwa
- kukuthandizani kuti mukhale odziyimira pawokha momwe mungathere
- sinthani moyo wanu komanso kukhala ndi thanzi labwino
Mitundu yosiyanasiyana ya kukonzanso khansa ikhoza kulangizidwa kwa inu. Izi zitha kutanthauza chilichonse chamitundumitundu za mautumiki monga:
- chithandizo chamankhwala, kusamalira ululu
- kukonza zakudya ndi masewera olimbitsa thupi
- uphungu wamalingaliro, ntchito ndi zachuma.
Chidule
- Burkitt Lymphoma ndi mtundu wovuta kwambiri wa khansa yomwe mungapeze - koma izi zikutanthauza kuti imayankha bwino kwambiri mukalandira chithandizo.
- Anthu ambiri omwe ali ndi Burkitt Lymphoma amatha kuchiritsidwa.
- Burkitt Lymphoma imachitika pamene B-cell lymphocyte yanu imakhala ndi khansa ndipo imatha kukhudza ana ndi akuluakulu.
- Mudzafunika chithandizo ndi chemo-immunotherapy mukangopezeka.
- Nthawi zina, lymphoma yanu singayankhe chithandizo, kapena ikhoza kubwereranso pambuyo pa chithandizo ndipo mudzafunika chithandizo chochulukirapo ngati izi zitachitika.
- Funsani dokotala wanu za mayesero azachipatala omwe mungakhale oyenerera.
